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. 2018 Sep 20;46(19):9960–9970. doi: 10.1093/nar/gky833

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Sequences of the (A) N1 riboswitch and (B) bacterial decoding A-site. (C, D) Crucial contacts of aminoglycoside 6′ group within A-site from the crystal structures (NEO complex, PDB ID 2ET4 (51), PAR complex: 1J7T (52)) and optimization protocol with hydrogen atoms of (53). (E, F) Two conformations of U1406 and U1495 found in the crystal structures of the A-site – PAR complex, PDB ID 1J7T and A-site – modified PAR complex, PDB ID 2BEE (54). Distances between non-hydrogen atoms are in Å. One crystal water molecule found close to uridines in the PAR complex is shown as a red sphere.