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. 2018 Sep 22;46(19):10246–10261. doi: 10.1093/nar/gky854

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — The RGG-box interacts with the G-quadruplex with abasic deoxyribose loops. (A) 2D ¹⁵N–¹H HSQC spectrum of the free RGG-box (black) and in complex with abasicloops-Tel22 DNA at 1:1 protein to DNA molar ratio (red). A representative cartoon of monomeric G-quadruplex form of abasicloops-Tel22 is shown. Specific chemical shift perturbations were observed for several residues (marked with green arrows). (B) A subset of residues of the RGG-box that show specific chemical shift perturbation upon addition of abasicloops-Tel22 is shown. The RGG-box and abasicloops-Tel22 complex was in fast exchange. Four steps of titrations at different protein to DNA ratios are shown: black at 1:0, green at 1:0.2, blue at 1:0.5 and red at 1:1.