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. 2018 Sep 22;46(19):9951–9959. doi: 10.1093/nar/gky857

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Modelling of the pH-dependent DNA nanocages. (A) Truncated octahedral DNA cage. Thick lines indicate double helices, thin lines the 5T linkers. (B) Top view of the truncated octahedral cage. (C) Top view of the T-cage, functionalized with two pH-dependent functional elements, at pH 5.0 and at (D) pH 8.0. (E) Model of the LT-cage, functionalized with two pH-dependent functional elements connected to the cage scaffold through seven-base spacers (yellow). The sequence of the clamp-switch triplex functional element is shown at the bottom of the figure. The green and black sequences represent the two strands interacting through the W-C interactions, the underlined sequence represents the 25 bases loop and the red sequence the third strand establishing at pH 5.0 the Hoogsteen hydrogen bonds with the double helix.