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. 2018 Sep 25;46(19):10514–10529. doi: 10.1093/nar/gky836

Figure 8.

Figure 8.

Comparison of the DNA binding mode of Rok with other winged helix proteins. The α3 helix are colored red and the wings are colored magenta. (A) The winged helix domain of Rok binds the minor groove of DNA with its wing W1 and α3 helix. (B) HNF-3γ binds the major groove of DNA with its α3 helix, assisted by wing W1 and W2 (PDB code: 1VTN). (C) RFX1 mainly binds the major groove with its wing W1, assisted by α3 helix contacting the minor groove (PDB code: 1DP7). (D) The DNA binding domain of PCG2 adopts an atypical winged helix fold, with two wings termed 20-loop and 80-loop binding the minor groove and α2 helix interacting with the major groove.