Table 3.
GH Secretion After Somatostatin Withdrawal and Injection of GHRH and GHRP2
| Group | D/T(−) | D/T(+) | D/T(+)/A/E2(−) | D/T(+)/A/E2(+) | ANOVA |
|---|---|---|---|---|---|
| Somatostatin withdrawal | |||||
| No. of subjects | 7 | 9 | 9 | 9 | |
| Mean GH, µg/L | 0.74 ± 0.41 | 0.67 ± 0.24 | 0.67 ± 0.17 | 0.79 ± 0.18 | 0.64 |
| Maximal GH concentration, µg/L | 1.9 ± 0.9 | 2.1 ± 0.8 | 1.7 ± 0.3 | 2.5 ± 0.6 | 0.65 |
| *Time of maximum, min | 90 ± 12 | 46 ± 7a | 96 ± 13 | 56 ± 10b | 0.004 |
| Pulsatile GH secretion, µg/L/2 h | 8.4 ± 5.1 | 5.8 ± 2.3 | 6.2 ± 2.1 | 6.8 ± 1.4 | 0.92 |
| GHRH/GHRP2 injection | |||||
| No. of subjects | 9 | 9 | 11 | 11 | |
| Mean GH, µg/L | 5.8 ± 0.8 | 8.0 ± 1.9 | 9.7 ± 2.2 | 9.9 ± 1.7 | 0.36 |
| Maximal GH concentration, µg/L | 16.1 ± 1.9 | 19.9 ± 4.1 | 21.1 ± 3.9 | 23.6 ± 3.7 | 0.53 |
| Time of maximum, min | 14.4 ± 1.8 | 14.4 ± 1.8 | 19.1 ± 1.6 | 18.2 ± 1.2c | 0.08 |
| Pulsatile GH secretion µg/L/2 h | 33.3 ± 4.1 | 51.9 ± 11.9 | 65.1 ± 15.6 | 62.5 ± 11.5 | 0.27 |
Data are shown as the mean ± SEM. Boldface denotes P < 0.05.
Abbreviations: A, anastrozole; D, degarelix; E2(+), 17β−Ε2 addback; E2(−), no 17β− E2 addback; T(+), testosterone addback; T(−), no testosterone addback.
a
T(−) vs T(+) post hoc contrast after ANOVA, P = 0.009.
b
E2(−) vs E2(+) post hoc contrast after ANOVA, P = 0.011.
c
Anastrozole vs no anastrozole post hoc contrast after ANOVA, P = 0.012.