TABLE 3.
Single nucleotide variant greater than 1% of the population for IC-derived chimeric and mutant viruses
| Single nucleotide variant |
Reference base |
Variant base |
Genomic position |
Gene region |
Coding/ noncoding |
Variant frequency (%) |
|---|---|---|---|---|---|---|
| Asibi/17D prME | ||||||
| G | A | 4517 | NS2B | Yes; A1467T | 4.12a | |
| C | T | 10384 | 3′ NCR | No | 1.39 | |
| G | A | 10394 | 3′ NCR | No | 1.10 | |
| G | T | 10652 | 3′ NCR | No | 1.55 | |
| 17D/Asibi prME | ||||||
| C | T | 10384 | 3′ NCR | No | 1.22 | |
| C | T | 10550 | 3′ NCR | No | 1.14 | |
| Asibi/17D NS4B-I95M | ||||||
| T | A | 818 | NS4A | Yes; S2234 | 1.50 | |
| 17D/Asibi NS4B-M95I | ||||||
| C | T | 10389 | 3′ NCR | No | 1.08 | |
| C | T | 10550 | 3′ NCR | No | 1.09 | |
a
The highest percentage is reported for SNV identified in both replicates.