TABLE 3.
Single nucleotide variant greater than 1% of the population for IC-derived chimeric and mutant viruses
Single nucleotide variant |
Reference base |
Variant base |
Genomic position |
Gene region |
Coding/ noncoding |
Variant frequency (%) |
---|---|---|---|---|---|---|
Asibi/17D prME | ||||||
G | A | 4517 | NS2B | Yes; A1467T | 4.12a | |
C | T | 10384 | 3′ NCR | No | 1.39 | |
G | A | 10394 | 3′ NCR | No | 1.10 | |
G | T | 10652 | 3′ NCR | No | 1.55 | |
17D/Asibi prME | ||||||
C | T | 10384 | 3′ NCR | No | 1.22 | |
C | T | 10550 | 3′ NCR | No | 1.14 | |
Asibi/17D NS4B-I95M | ||||||
T | A | 818 | NS4A | Yes; S2234 | 1.50 | |
17D/Asibi NS4B-M95I | ||||||
C | T | 10389 | 3′ NCR | No | 1.08 | |
C | T | 10550 | 3′ NCR | No | 1.09 |
The highest percentage is reported for SNV identified in both replicates.