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Genomic instability induced by prolonged BCR-ABL1 expression affects GC-poor, late-replicating sequences irrespective of initial ploidy in TF1. Cdfs of GC content (A, B) and MRT in TF1 GFP (C, D) according to ploidy status at Step 1 (A, C) and evolution at Step 2 (B, D) of CML progression.
