Figure 11.

Origin silencing events are enriched in genomic regions destabilized by BCR-ABL1 expression, independently of initial ploidy and before obvious genome instability. Relative densities of IZ efficiency changes (New, Enhanced, Weakened and Silenced) at Step 1 (black; n = 476) or Step 2 (yellow; n = 774) of CML progression according to ploidy status at Step 1 (A, B) and ploidy evolution at Step 2 (C, D). Absolute densities of each type of IZ efficiency change in indicated regions (2N, 3N, Stable, Unstable) were normalized by their average over the whole genome (dashed lines). Error bars represent a 95% confidence interval assuming data counts are from a Poisson distribution.