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. 2018 Sep 5;46(19):10157–10172. doi: 10.1093/nar/gky797

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Manual annotation of RFD profile changes during the first two steps of the CML progression model. (A–D) RFD profiles computed in 10 kb non-overlapping windows for TF1-GFP (black), TF1-BrcAbl-1M (yellow) and TF1-BrcAbl-6M (blue) are visualised in 2 Mb regions along the 22 human autosomes. (A) Region along chromosome 12 where RFD profiles in the 3 cell lines do not present any significant difference. (B) Region along chromosome 2 illustrating IZs whose efficiency is repeatedly enhanced (green) or weakened (purple) in Steps 1 and 2 of the model CML progression. (C) Region along chromosome 18 having two IZ efficiency changes in Step 1 (enhanced, leftmost green; weakened, purple) that are confirmed in Step 2. The rightmost green line marks an IZ which is repeatedly enhanced at Steps 1 and 2 (as in B). (D) Region along chromosome 5 illustrating an IZ activated during Step 1 (red line) and silenced during Step 2.