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. 2018 Sep 20;46(19):10195–10215. doi: 10.1093/nar/gky804

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — BCL2 or MCL1 is inferior to BCL-XL in promoting iPSC survival and editing efficiency. (A and B) Effects of BCL2 and MCL1 on human iPSC survival and editing. Cell survival was determined by cell count on day 1 after electroporation. KI or KO efficiency was determined on day 3 or 7 by FACS; n = 4–5. (C) Relative expression of Cas9 and sgRNA by RT-qPCR; n = 6. RT-qPCR analysis was conducted 8 hours after electroporation; *P < 0.05; **P < 0.01; ***P < 0.001; ns = not significant.