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. 2018 Sep 20;46(19):10195–10215. doi: 10.1093/nar/gky804

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — BCL inhibition further increases editing efficiency in BCL-XL transfected iPSCs. (A) Combined treatment of ABT-263, a BCL inhibitor, compromises survival yet improves editing. Treatment of ABT-263 (1 μM, 8–24 h) compromises cell survival by 70% (left, n = 3), while further improving PRDM14 KI efficiency (right, n = 3). (B) Treatment of ABT-263 (1 μM, 8–24 h) compromises cell survival by 80% (left, n = 4), while further improving CD326 KO efficiency (right, n = 4); **P < 0.01.