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. 2018 Sep 20;46(19):10195–10215. doi: 10.1093/nar/gky804

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — HDR/NHEJ editing efficiencies with double cut donors or ssODN donors as determined by high-throughput sequencing. (A and B) Indels (HDR + NHEJ), HDR efficiency, and HDR percentage in all edited cells at EEF1A1 (A) and GAPDH (B) with pDonor-sg (double cut donor) in iPSCs; HDR percentage was calculated by the ratio of HDR to HDR plus NHEJ. (C–E) Indels (HDR + NHEJ), HDR efficiency, and HDR percentage in all edited cells at AAVS1 (C), CD326 (D), and GAPDH (E) using ssODN donors (single-stranded oligo DNAs) in iPSCs. The nucleofections were conducted without (Control) or with BCL-XL/BCL2; n = 3; *P < 0.05, **P < 0.01, ***P < 0.001; ns = not significant.