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(a) Photographs of 4T1-tumor-bearing mice and their tumor regions 13 days after the treatment; (b) H&E staining for pathological changes in tumor tissues from each group to reveal the effectiveness of in vivo chemo-sonodynamic therapy by intravenous/intratumoral administration of DESN; (c) TUNEL staining for pathological changes in tumor tissues and (d) Antigen Ki-67 immunofluorescence staining for cellular proliferation in tumor sections.
