Scheme 2.

Schematic illustration of the process of killing tumor cells by DESN-mediated dual-model chemo-sonodynamic therapy upon low-energy ultrasound. When drugs are delivered in the body, as a result of this targeting, the drugs accumulate in tumor cells, which increases drug utilization. The dual-effect nanoparticles (DESN), with the function of accelerating the drug release at the desired site and enhancing the cavitation effect under low-energy ultrasound irradiation, have an excellent inhibiting effect on tumor cells in vivo.