Figure 5.

Representative histological images of the pancreas stained with hematoxylin and eosin, 400×. (A) Control animal. The acinar cells displayed normal architecture. (B) T5 showed only minimal acinar cell degranulation. (C) T4, (D) T7, and (E) T8. Variable slight to moderate effects were characterized by reduced numbers of eosinophilic zymogen granules, pyknotic nuclei with shrunken cytoplasm (arrows), and atrophic and/or vacuolated cytoplasm (arrowheads). (F) T2. Massive necrosis with apoptosis of acinar cells occurred in the lobular area and normal architecture was disrupted.