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Suppression effect of splenic MDSCs in STDME-fed mice after AOM/DSS-induced CAC. Splenocytes from control or STDME-fed CAC-induced mice were isolated. The expression levels of Gr-1 on CD11b+ cells were analyzed by flow cytometry. Each bar represents mean ± SEM and data were assessed by a Mann-Whitney U-test. ** p < 0.01; *** p < 0.001; ns = not significant; n = 10/group. STDME, selenoneine-containing tuna dark muscle extract.
