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. 2018 Oct 2;19(10):3009. doi: 10.3390/ijms19103009

Figure 3.

Figure 3

Effects of LPS on 1-MT concentrations in plasma (A) and tissues (B). Treatment with NaCl was used as a control. MYR-pre-treated animals are not shown due to the absence of 1-MT. 1-MT was quantified using MS/MS. LPS or NaCl (indicated by black arrows) were injected i.p. directly after blood sampling at 0 h. The animals received the fifth s.c. 1-MT injection at 12 h after LPS/NaCl treatment as indicated. The data are presented as LS-means ± SE. In plasma (A), significant differences between the time points were calculated using the Tukey–Kramer test and indicated by hashes within each treatment group. Significant differences between LPS and NaCl groups (p < 0.05) are indicated using differing letters (A, B). For time points 0, 1, 3, 6 h: n = 12/group. For time point 24 h: n = 6/group. The data for 1-MT in tissues (B) include both sampling times (6 and 24 h, n = 12/group) after i.p. application. Significant differences between LPS and NaCl treatment were calculated using the Tukey–Kramer test and are indicated for each tissue, respectively. # p < 0.01.