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. 2018 Oct 2;19(10):3009. doi: 10.3390/ijms19103009

Figure 5.

Figure 5

Effects of LPS on plasma TNF-α (A), plasma IL-10 (B) and skin temperature (C) and its interference by 1-MT. Treatment with NaCl and pre-treatment with MYR were used as control groups. LPS or NaCl were injected i.p. directly after blood sampling at 0 h, respectively. The animals received the fifth s.c. 1-MT injection at 12 h after LPS/NaCl treatment to prevent a decline in 1-MT levels during the period of the LPS response. The cytokines TNF-α and IL-10 were quantified by ELISA. Skin temperature was measured using an infrared thermometer directly before blood sampling. All data are presented as LS-means ± SE. For multiple pair-wise comparisons Tukey–Kramer procedure was used. Significant differences between time points are indicated by hashes. For time points 0, 1, 3, 6 h: n = 11-12/group (total n = 47); for time points 12 and 24 h: n = 5-6/group (total n = 23); # p < 0.01.