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. 2018 Sep 21;10(10):1349. doi: 10.3390/nu10101349

Figure 2.

Figure 2

Sucrosomial® Iron and Ferrous Sulfate treatment of anemic mice rescued the anemia. (A) Scheme of the treatment protocol: healthy mice were maintained for 6–8 weeks in iron free-diet to reach hemoglobin level <12 g/dL, then in presence of iron free diet they were treated daily with Saline, Vehicle, Sucrosomial® Iron and Ferrous Sulfate (1 mg/kg) by gavage for 2 weeks. (B) Hemoglobin and (C) hematocrit level in mice after the treatments; (D) Representative image of peripheral blood smear (May–Grünwald staining) of treated mice (Saline, Vehicle, Sucrosomial® Iron, Ferrous Sulfate) in presence of iron-free diet (ID) compared to healthy mice (on the right, control mouse) maintained in iron-balanced diet (IB). (E) Serum iron content. (F) Transferrin saturation (TSat) content in the four treated groups. In E and F Saline (circles), Vehicle (squares), Sucrosomial® Iron (triangles), Ferrous Sulfate (diamonds) and iron balance group (inverted triangles). p values were obtained by one-way ANOVA comparing Sucrosomial® Iron and ferrous sulfate versus saline and vehicle.