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PG102 downregulates expression of antimicrobial peptides on M5-stimulated HaCaT cells in a dose-dependent manner. (A) Real-time PCR (qPCR) analysis of mRNA expression levels of antimicrobial peptides after 24 h. (B) Protein levels of antimicrobial peptides measured in the cultured supernatant by ELISA after 48 h. BD-2, beta-defensin 2; S100, S100 calcium binding protein. #### p < 0.0001 versus negative control group; * p < 0.05, **** p < 0.0001 versus M5-only treated group.
