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Tumor volume and body weight changes (BWC) in SW620 and COLO205 xenografted mice after daily oral sequential administration of trifluridine/tipiracil (FTD/TPI) and regorafenib. Xenografted mice were randomized on day 0. FTD/TPI (150 mg/kg) and regorafenib (10 mg/kg) were administered orally twice and once daily, respectively, from days 1 to 14. (A,B) Tumor volume changes and (C,D) body weight changes in SW620 and COLO205 xenografts, respectively. Values indicate mean ± SD (n = 6).
