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. 2018 Oct 7;19(10):3058. doi: 10.3390/ijms19103058

Figure 6.

Figure 6

Resveratrol inhibits S. aureus-induced VCAM-1 expression and inflammatory signaling pathways. (A) Cells were pretreated with resveratrol for 24 h, and then incubated with S. aureus for 4 h or 6 h. The mRNA levels and promoter activity of VCAM-1 were determined. (B) Cells were pretreated with resveratrol for 24 h, and then incubated with S. aureus for 24 h. The THP-1 cells adherence was measured. (C–E) Cells were pretreated without or with resveratrol for 24 h, and then incubated with S. aureus for the indicated times. The expression of phospho-c-Src, phospho-PDGFR, phospho-p38 MAPK, phospho-JNK1/2, phospho-c-Jun, and phospho-ATF2 were determined by Western blot. (F) Cells were pretreated with resveratrol for 24 h, and then incubated with S. aureus for 4 h. ATF2 and c-Jun binding activities were analyzed by a ChIP assay. n = 3–4, # p < 0.01, as compared with the cells exposed to S. aureus alone.