Figure 7.

Resveratrol inhibits S. aureus-induced VCAM-1 expression in the lungs of mice. (A) Mice were intraperitoneal given one dose of PP1, AG1296, SP600125, SB202190, or Tanshinone IIA for 2 h prior to S. aureus (2 × 10⁷ CFU/mouse) treatment, and sacrificed after 24 h. Preparation of lung tissues was analyzed by real-time PCR to determine the levels of VCAM-1 mRNA. (B) Mice were intraperitoneal given one dose of resveratrol for 24 h prior to S. aureus (2 × 10⁷ CFU/mouse) treatment, and sacrificed after 24 h. Preparation of lung tissues was analyzed by real-time PCR to determine the levels of VCAM-1 mRNA. (C) Mice were intraperitoneal given one dose of resveratrol for 24 h prior to S. aureus (2 × 10⁷ CFU/mouse) treatment, and sacrificed after 24 h. Bronchoalveolar lavage (BAL) fluid was acquired and leukocyte count was determined. n = 4–5, # p < 0.01, as compared with the mice exposed to S. aureus alone.