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. 2018 Sep 30;19(10):2993. doi: 10.3390/ijms19102993

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Fluorescein angiographic analysis of choroidal neovascularization (CNV) lesions after an intravitreal or daily topical application of CAD27. (A) A schematic diagram of the timeline for the laser-induced CNV rat model, treatments, and examination. Choroidal vascularity of laser-induced CNV lesions was examined by FFA (day 24) and choroidal flat-mount labeling with FITC-dextran (day 28) after a single intravitreal injection or daily topical application of CAD27. (B) Representative CNV lesions in rat eyes were identified by fundus fluorescein angiography after an intravitreal or daily topical application of CAD27. Yellow arrows indicated the lesions of CNV. (C) CNV lesions from fluorescein angiography were analyzed at days 24 after treatment, and data are presented as percentage of CNV score (n = 26–46 from 6 to 8 eyes). Score 1 (green) indicates staining, Score 2 (yellow) indicates moderate leakage, and Score 3 (red) indicates heavy leakage. Lu: Lucentis^®, IVI: intravitreal injection, TA: topical application.