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. 2018 Sep 30;19(10):2993. doi: 10.3390/ijms19102993

Figure 5.

Figure 5

Flat-mount analysis of choroidal vascularity after an intravitreal or daily topical application of CAD27. Choroidal vascularity of laser-induced CNV lesions was examined by labeling using FITC-dextran. (A) Representative profile of FITC-dextran-positive blood vessels in choroidal flat-mounts at day 28 after treatment. Scale bar: 200 μm. (B) FITC-dextran labeling CNV in the choroidal flat-mounts was quantified and data are presented as mean ± SEM (n = 26–31 from 6 to 8 eyes) using one-way ANOVA followed by Tukey’s multiple comparisons test (* p < 0.05, ** p < 0.001, *** p < 0.0001). White area indicated the lesions of CNV in choroid flat-mount. Lu: Lucentis®, IVI: intravitreal injection, TA: topical application.