Table 3.

Metformin reduces inflammation.

Tissues	Metformin Effects and Mechanism	Subjects	References
Hepatocyte	Phosphorylation of C-JUNK-1 decreased	Obese mice	[23]
	AMPK activation increased	Obese mice	[23]
Adipocyte	PFKFB3/iPFK2 increased	3T3L-1 cell	[37]
Macrophages	IL-1β, IL-6 and TNF-α decreased	Obese mice	[42]
	Alteration of macrophage polarization	Mice	[41]