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. 2018 Sep 28;10(10):530. doi: 10.3390/v10100530

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Flavivirus replication cycle and genome structure. (A) The flavivirus enters the host cell by attaching to specific receptors (1) which then leads to its endocytosis (2) followed by fusion to a lysosome into an acidic environment (3). The genome is released from the endolysosome (4) which is then translated on the Endoplasmic reticulum membrane (5) and post translational processing is done in the Golgi apparatus (6). The mature virus then buds off from the Golgi network (7) to the extracellular space via exocytosis (8, 9). (B) The genome consists of three structural proteins (Envelope (E), Capsid (C) and pre-membrane (prM)) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NSB, and NS5).