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. 2018 Oct 6;19(10):3049. doi: 10.3390/ijms19103049

Figure 2.

Figure 2

Reorientation of the RecG motor domain to accommodate parental DNA. (a) The RecG/DNA crystal structure (PDB ID 1GM5), rotated 90° with respect to the view shown in Figure 1b. The wedge domain is colored green, the linker domain is grey, and the ATPase motor is blue (N-lobe) and red (C-lobe). Parental DNA (yellow) was modeled by superposition of the XPB-ATPase and its bound DNA from the TFIIH complex (PDB ID 5IY9) onto the RecG-ATPase domain. The curved black arrow denotes the rotation of the motor domain necessary to align the helical axis of the modeled DNA to that of the crystal structure. (b) Model of RecG bound to parental DNA after 30° rotation of the RecG motor and its accompanying DNA. (c) Schematic of the rotation of the motor domain needed to bring parental duplex into alignment with the fork.