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The 3-D-surface and contour response plots generated from a quadratic model representing the combined effects of temperature, pH, and salinity on the growth rate (A–C) and carotenoids content (D–F) by liquid cultures of Hfx. mediterranei. The interactions between salinity and temperature (A) and (D); pH and temperature (B) and (E), and pH and salinity (C) and (F) were analyzed. Other details of experimental conditions are stated in the Materials and Methods section.
