3D QSAR	Three-dimensional structure-activity relationship
AMPA	α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
cAMP	Cyclic adenosine monophosphate
CAR	Conditioned avoidance response
CNS	Central nervous system
cNT PDEs	Cyclic nucleotide phosphodiestereases
EPS	Extrapyramidal symptoms
FDA	Food and Drug Administration
GABA	γ-Aminobutyric acid
GPCRs	G protein-coupled receptors
GSK-3	Glycogen synthase kinase-3
GTP	Guanosine-5′-triphosphate
LSD	Lysergic acid diethylamide
MTDs	Multi-target drugs
NMDA	N-methyl-d-aspartate
PCP	Phencyclidine
SSRI	Selective serotonin reuptake inhibitor
VTA	Ventral tegmental area