Table 3.
Major changes in the expression of gene orthologues of AthCV1-infected Aspergillus species compared to their isogenic AthCV1-free lines.
| Fold Change in AthCV1-infected Samples | Gene and Function From www.uniport.org & www.aspergillusgenome.org |
||||
|---|---|---|---|---|---|
| Gene ID A. nidulans |
A. thermomutatus | A. fumigatus | A. nidulans | A. niger | |
| AN10660 | - | 25 | - | 18 | ndiA; Pyridine nucleotide-disulphide oxidoreductase, putative; NADPH dehydrogenase activity and spore germination. |
| AN2755 | −35 | - | −16 | - | MAT1: Alpha-domain mating-type protein; regulator of sexual development; acts with Mat2 HMG domain protein. |
| AN1652 | - | −5 | - | - | sebA; C2H2 transcription factor; required for virulence; response to oxidative stress and heat shock. |
| AN5781 | - | 31 | 6 | 157 | Heat shock protein Hsp30, transcript increase during the unfolded-protein response; palA-dependent expression independent of pH |
| AN2458 | 3 | - | −5 | - | canadA-C; orthologue(s) N-terminal subunit of Cand1; sexual development, secondary metabolism and light control of asexual development. |
| AN10306 | 5 | - | −5 | 3 | candA-N; role in sexual development and secondary metabolism. |
| AN10049 | - | 9 | −4 | - | mdpB; Probable scytalone dehydratase; involved in conidial pigment biosynthesis, conidium formation and sporulation. |
| AN5836 | - | - | −4 | −5 | stuA; Positive regulation of asexual sporulation and conidiophore development. |
| AN1848 | - | −2 | −20 | −326 | nosA; Zinc(II)2Cys6 putative transcription factor; positive regulation of sexual development. |
| AN5156 | −2 | - | 6 | - | Pho80-like cyclin; overexpression decreases conidiation and increases cleistothecia. |
| AN7169 | −100 | 4 | 12 | 12 | fhbA; Flavohemoglobin, negative regulation of sexual sporulation and positive regulation of sterigmatocystin biosynthesis. |
| AN0807 | −1913 | −2 | - | −4 | laeA; Methyltransferase-domain protein; self-methylates; coordinates asexual development in response to light; regulates secondary metabolism and is required for Hulle cell formation. |
| AN0387 | - | 2 | −37 | - | cryA: Negative regulation of cleistothecium development. |
| AN4783 | 7 | - | −2 | - | csnB; COP9 signalosome subunit 2 (CsnB) formation of cleistothecia. |
| AN2421 | 4 | −3 | - | −31 | flbC: regulation of conidium formation and spore germination. |
| AN7553 | - | −3 | −5 | - | devR; Basic helix-loop-helix transcription factor; conidiophore development. |
| AN5893 | −5 | 2 | - | - | flbA; Developmental regulator FlbA, conidiophore development and asexual sporulation. |
| AN0082 | −6 | −2 | −2 | −2 | phnA; Phosducin, putative; regulates sporulation |
| AN3387 | - | 2 | 16 | −2 | gprD: Deletion of gprD resulted in delayed conidial germination and enhanced sexual development. |
| AN0279 | - | −2 | 2 | −12 | flbD: Myb-like DNA-binding protein; positive regulation of conidiation. |
| AN2290 | - | - | - | −5 | steA; Sexual development transcription factor SteA; Required for cleistothecial development and ascosporogenesis. Not required for conidiation. |
| AN0170 | - | - | - | −24 | trxA; Thioredoxin, required for conidiation; expression upregulated after exposure to farnesol. |
| AN9121 | 2 | - | - | −200 | esdC; sexual development protein, involved in early sexual development and regulated by VeA and FlbA. |
| AN4163 | - | 2 | −11 | - | cpcB: G-protein complex beta subunit CpcB; positive regulation of cleistothecium development. |
| AN1017 | 2 | −2 | −6 | 2 | hogA; Putative mitogen-activated protein kinase; required for sexual development and sporulation. |
| AN7795 | - | - | 39 | - | gprK; positive regulation of sexual sporulation [40]. |
| Up-regulated | Down-regulated | ||||
| Colour | Fold change | Colour | Fold change | ||
| <5 | <5 | ||||
| 5 to 20 | 5 to 20 | ||||
| 21 to 100 | 21 to 100 | ||||
| 101 to 500 | 101 to 500 | ||||
| > 500 | > 500 | ||||