Table 6.

Categories of biological functions with diseases or function annotation activated by 1,25(OH)₂D3 in human epidermal keratinocytes after 6 h of treatment.

Categories of Biological Function	Diseases or Functions Annotation	p-Value	Activation z-Score	# of Genes
Cancer, Organismal Injury and Abnormalities	growth of tumor	1.5 × 10−12	0.033	31
Cellular Movement	cell movement	4.5 × 10−12	1.845	52
Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology	proliferation of tumor cells	7.5 × 10−12	−0.27	23
Cellular Movement	migration of cells	1.3 × 10−11	1.801	48
Cellular Growth and Proliferation	proliferation of cells	4.2 × 10−11	0.347	70
Carbohydrate Metabolism	metabolism of polysaccharide	4.4 × 10−11	0.755	16
Cell Death and Survival	apoptosis of tumor cell lines	8.3 × 10−11	1.089	36
Cellular Movement	invasion of cells	8.7 × 10−11	0.571	30
Inflammatory Response	inflammatory response	1.4 × 10−10	0.766	28
Cellular Development	differentiation of cells	1.5 × 10−10	2.774	51
Cell Death and Survival	cell survival	3.1 × 10−10	2.346	38
Cell Death and Survival	apoptosis	5.7 × 10−10	1.307	55
Cell Death and Survival	necrosis	6.3 × 10−10	1.7	54
Cell Death and Survival	cell viability	6.4 × 10−10	2.547	36
Tissue Morphology	quantity of cells	7.1 × 10−10	1.065	43
Cardiovascular System Development and Function, Organismal Development	vasculogenesis	9.4 × 10−10	0.844	26
Carbohydrate Metabolism	synthesis of polysaccharide	9.6 × 10−10	0.297	13
Cellular Growth and Proliferation, Tissue Development	proliferation of connective tissue cells	1.2 × 10−9	1.232	23
Cellular Movement	cell movement of tumor cell lines	1.2 × 10−9	0.955	28
Cell Death and Survival	cell death of tumor cell lines	1.2 × 10−9	0.81	39
Cellular Development, Cellular Growth and Proliferation	proliferation of tumor cell lines	1.9 × 10−9	0.324	39
Organismal Survival	morbidity or mortality	2.3 × 10−9	−1.006	51
Embryonic Development, Organismal Development	development of body trunk	2.7 × 10−9	0.06	32
Cell Death and Survival	cell death	3.1 × 10−9	1.556	62
Cancer, Organismal Injury and Abnormalities	growth of malignant tumor	3.3 × 10−9	0.518	19
Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function, Tissue Development	proliferation of fibroblasts	4.0 × 10−9	0.604	17
Cellular Function and Maintenance, Hematological System Development and Function	function of myeloid cells	4.5 × 10−9		14
Cell Signaling, Small Molecule Biochemistry	synthesis of nitric oxide	4.7 × 10−9	0.89	15
Dermatological Diseases and Conditions	psoriasis	5.0 × 10−9		22