Table 12.
Categories of biological functions with diseases or function annotation activated by 1,25(OH)2D3 in human epidermal keratinocytes after 24 of treatment.
| Categories of Biological Function | Diseases or Functions Annotation | p-Value | Activation z-Score | # of Genes |
|---|---|---|---|---|
| Cancer, Organismal Injury and Abnormalities | benign neoplasia | 1.0 × 10−9 | 0.927 | 26 |
| Dermatological Diseases and Conditions | psoriasis | 2.6 × 10−9 | 20 | |
| Cardiovascular System Development and Function, Cellular Movement | cell movement of endothelial cells | 8.8 × 10−9 | 1.37 | 15 |
| Cancer, Cellular Movement, Organismal Injury and Abnormalities, Tumor Morphology | invasion of tumor cells | 1.2 × 10−8 | 1.596 | 11 |
| Cell Signaling, Small Molecule Biochemistry | synthesis of nitric oxide | 1.9 × 10−8 | −0.217 | 13 |
| Cardiovascular System Development and Function, Cellular Movement | homing of endothelial cells | 3.2 × 10−8 | 1.597 | 7 |
| Cancer, Organismal Injury and Abnormalities, Tumor Morphology | invasion of tumor | 3.4 × 10−8 | 1.63 | 12 |
| Lipid Metabolism, Small Molecule Biochemistry | metabolism of eicosanoid | 3.4 × 10−8 | 2.747 | 12 |
| Cardiovascular Disease, Hematological Disease | Thrombosis | 5.9 × 10−8 | −0.946 | 10 |
| Organismal Injury and Abnormalities | Fibrosis | 1.1 × 10−7 | −1.401 | 17 |
| Lipid Metabolism, Small Molecule Biochemistry | metabolism of prostaglandin | 1.2 × 10−7 | 2.589 | 10 |
| Immunological Disease | hypersensitive reaction | 1.5 × 10−7 | 0.914 | 15 |
| Cardiovascular System Development and Function, Organismal Development | vasculogenesis | 1.6 × 10−7 | 1.825 | 20 |
| Inflammatory Response | inflammation of organ | 1.8 × 10−7 | −0.022 | 26 |
| Dermatological Diseases and Conditions, Inflammatory Disease, Inflammatory Response | Dermatitis | 1.8 × 10−7 | −0.355 | 15 |
| Cardiovascular System Development and Function, Organismal Development | vascularization of hindlimb | 2.3 X 10−7 | 1.994 | 4 |
| Cellular Movement | homing | 3.4 × 10−7 | 1.468 | 17 |
| Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology | proliferation of tumor cells | 5.4 × 10−7 | −0.189 | 15 |
| Cancer, Organismal Injury and Abnormalities | growth of tumor | 6.0 × 10−7 | 0.402 | 20 |
| Cellular Movement | invasion of cells | 6.3 × 10−7 | 1.731 | 21 |