Table 2.
Effect of resveratrol on polyol pathway and the advanced glycation end products (AGEs) content and sulfhydryl groups (-SH groups) content in lens in diabetic rats.
| Parameter/Group | C | D | D+R10 | D+R20 |
|---|---|---|---|---|
| Glucose in the lens (mg/g lens) | 0.16 ± 0.03 | 0.83 ± 0.07 *** | 1.02 ± 1.00 *** | 0.80 ± 0.07 *** |
| Sorbitol (µmol/g lens) | 1.26 ± 0.05 | 30.10 ± 0.47 *** | 29.42 ± 0.70 *** | 30.73 ± 0.66 *** |
| Fructose in the lens (µmol/g lens) | 0.08 ± 0.01 | 0.13 ± 0.01 *** | 0.14 ± 0.01 *** | 0.13 ± 0.01 *** |
| Aldose reductase (nmol/min/mg protein) | 0.085 ± 0.003 | 0.107 ± 0.008 * | 0.102 ± 0.003 ** | 0.109 ± 0.005 * |
| Sorbitol dehydrogenase (µU/mg protein) | 1.94 ± 0.18 | 3.01 ± 0.34 * | 2.33 ± 0.14 | 2.67 ± 0.15 * |
| AGEs (µg/g lens) | 5.80 ± 0.32 | 10.17 ± 0.29 *** | 10.30 ± 0.12 *** | 9.94 ± 0.50 *** |
| -SH groups (nmol/g lens) | 3.63 ± 0.13 | 3.09 ± 0.15 | 3.38 ± 0.20 | 3.91 ± 0.34 |
C—control, non-diabetic rats; D—diabetic rats; D+R10—diabetic rats receiving resveratrol (10 mg/kg po for 4 weeks); D+R20—diabetic rats receiving resveratrol (20 mg/kg po for 4 weeks). Results are presented as means ± SEM (n = 8–9). * p < 0.05, ** p < 0.01, *** p < 0.001—statistically significantly different from the C group.