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. 2018 Sep 28;10(10):1381. doi: 10.3390/nu10101381

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of DKB114 on the expression of uric acid transporters in kidney of rats with PO-induced hyperuricemia. (A) Representative proteins expression levels determined by western blot. (B) URAT1, (C) GLUT9, (D) OAT1, and (E) OAT3 protein expression levels. Kidney tissue for analysis of protein expression levels was harvested in Exp2. NC, normal control group; PO, potassium oxonate-induced hyperuricemia group; DKB114, a mixture of ethanol extracts of Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Presl bark (CB) in a 1:2 ratio; Ben 50: 50 mg/kg benzbromarone. Data are expressed as the mean ± SEM (n = 6). ^# p < 0.05 vs. the NC group; * p < 0.05 vs. the PO group.