Figure 2.

An unsupervised hierarchical clustering analysis of the graft supernatant levels of IL-6 family cytokines/receptors after stem cell mobilization by G-CSF and harvesting by leukapheresis. The analysis included 19 donors because a graft sample was not available for patient 6. The mediator concentrations were normalized to the corresponding median level for each mediator and, thereafter, log2 transformed before an unsupervised hierarchical clustering with Euclidian distance measurement and complete linkage was performed. The color scale thus corresponds to the Euclidian distance from the median since values were normalized to the corresponding median value, i.e., two measurements with the same color show the same distance from the median. The results are presented as dendrograms and a heat map for visualization and interpretation. The individual donors are indicated at the top of the figure whereas the different mediators are presented vertically in the right part of the figure.