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RSG encapsulation efficiency (EE) and drug loading (DL) in different NP formulations prepared by emulsion-evaporation or nanoprecipitation, with different RSG starting amounts (4, 7, or 10 mg). DCM = dichloromethane, ACN = acetonitrile.
| Solvent Mixture | Emulsion-Evaporation | Nanoprecipitation | ||
|---|---|---|---|---|
| EE (%) | DL (%) | EE (%) | DL (%) | |
| Acetone/DCM 10 mg | 4.7 | 0.47 | ||
| ethyl acetate/DCM 10 mg | 5.7 | 0.56 | ||
| ACN 10 mg | 22 | 2.1 | ||
| ACN 7 mg | 30 | 2.0 | ||
| ACN 4 mg | 32 | 1.3 | ||
| Acetone 10 mg | 22 | 2.1 | ||
| Acetone 7 mg | 23 | 1.6 | ||
| Acetone 4 mg | 41 | 1.6 | ||
