Table 3.

The significance of miRNA panels as diagnostic and prognostic biomarkers of colorectal cancer.

MiRNA Panel	Biomarker Type	Regulation in CRC	Source of miRNA	Cohort Size	Correlation/Differentiation	Detection Method	Authors
miR-15b miR-17 miR-21 miR-26b miR-145	diagnostic	up-regulation	plasma	n = 280	control vs. CRC	qRT-PCR	Pan et al. [133]
miR-1246 miR-202-3p miR-21-3p miR-1229-3p miR-532-3p	diagnostic	up-regulation (miR-1246, miR-1229-3p, miR-532-3p) down-regulation (miR-202-3p, miR-21-3p)	serum	n = 575	control vs. CRC vs. colorectal adenomas	qRT-PCR	Guo et al. [134]
miR-19a-3p miR-21-5p miR-425-5p	diagnostic	up-regulation	serum	n = 334	control vs. CRC	qRT-PCR	Zhu et al. [135]
miR-409-3p miR-7 miR-93	diagnostic	up-regulation (miR-409-3p) down-regulation (miR-7, miR-93)	plasma	n = 241	control vs. CRC	miRNA microarrays, qRT-PCR	Wang et al. [136]
miR-431 miR-15b miR-139-3p	diagnostic	up-regulation	plasma	n = 87	control vs. stage IV CRC	microfluidic array technology, qRT-PCR	Kanaan et al. [137]
miR-431 miR-139-3p	diagnostic	up-regulation	plasma	n = 87	control vs. CRC	microfluidic array technology, qRT-PCR	Kanaan et al. [137]
miR-331 miR-15b miR-21 miR-142-3p miR-339-3p	diagnostic	up-regulation	plasma	n = 87	colorectal adenomas vs. CRC	microfluidic array technology, qRT-PCR	Kanaan et al. [137]
miR-18a miR-21 miR-22 miR-25	diagnostic	up-regulation (miR-18a, miR-21, miR-25) down-regulation (miR-22)	plasma	n = 201	control vs. CRC	semi-quantitative RT-PCR	Wikberg et al. [138]
miR-7 miR-93 miR-195 miR-141 miR-494 let-7b	prognostic	up-regulation (miR-7, miR-141, miR-494) down-regulation (miR-93, miR-195, let-7b))	tissues	n = 104	non-early relapsed CRC vs. early relapsed CRC	qRT-PCR	Yang et al. [139]
miR-21 miR-15b miR-29a miR-92a miR-125b miR-223	diagnostic	up-regulation	serum	n = 163	control vs. CRC	qRT-PCR	Liu et al. [140]