Table 3.
MiRNA Panel | Biomarker Type | Regulation in CRC | Source of miRNA | Cohort Size | Correlation/Differentiation | Detection Method | Authors |
---|---|---|---|---|---|---|---|
miR-15b miR-17 miR-21 miR-26b miR-145 |
diagnostic | up-regulation | plasma | n = 280 | control vs. CRC | qRT-PCR | Pan et al. [133] |
miR-1246 miR-202-3p miR-21-3p miR-1229-3p miR-532-3p |
diagnostic | up-regulation (miR-1246, miR-1229-3p, miR-532-3p) down-regulation (miR-202-3p, miR-21-3p) |
serum | n = 575 | control vs. CRC vs. colorectal adenomas | qRT-PCR | Guo et al. [134] |
miR-19a-3p miR-21-5p miR-425-5p |
diagnostic | up-regulation | serum | n = 334 | control vs. CRC | qRT-PCR | Zhu et al. [135] |
miR-409-3p miR-7 miR-93 |
diagnostic | up-regulation (miR-409-3p) down-regulation (miR-7, miR-93) |
plasma | n = 241 | control vs. CRC | miRNA microarrays, qRT-PCR | Wang et al. [136] |
miR-431 miR-15b miR-139-3p |
diagnostic | up-regulation | plasma | n = 87 | control vs. stage IV CRC | microfluidic array technology, qRT-PCR | Kanaan et al. [137] |
miR-431 miR-139-3p |
diagnostic | up-regulation | plasma | n = 87 | control vs. CRC | microfluidic array technology, qRT-PCR | Kanaan et al. [137] |
miR-331 miR-15b miR-21 miR-142-3p miR-339-3p |
diagnostic | up-regulation | plasma | n = 87 | colorectal adenomas vs. CRC | microfluidic array technology, qRT-PCR | Kanaan et al. [137] |
miR-18a miR-21 miR-22 miR-25 |
diagnostic | up-regulation (miR-18a, miR-21, miR-25) down-regulation (miR-22) |
plasma | n = 201 | control vs. CRC | semi-quantitative RT-PCR | Wikberg et al. [138] |
miR-7 miR-93 miR-195 miR-141 miR-494 let-7b |
prognostic | up-regulation (miR-7, miR-141, miR-494) down-regulation (miR-93, miR-195, let-7b)) |
tissues | n = 104 | non-early relapsed CRC vs. early relapsed CRC | qRT-PCR | Yang et al. [139] |
miR-21 miR-15b miR-29a miR-92a miR-125b miR-223 |
diagnostic | up-regulation | serum | n = 163 | control vs. CRC | qRT-PCR | Liu et al. [140] |