Table 1.
The top 10 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in weight reduction in C57BL/6, Tlr5, Tlr2, Tlr4 mice.
| Term | Term ID | Total Genes of the Term | Union Targets in the Term | Mirnas in the Term | Score |
|---|---|---|---|---|---|
| C57BL/6 | |||||
| T CELL RECEPTOR SIGNALING PATHWAY | 4660 | 109 | 7 | 3 | 1.869 |
| AXON GUIDANCE | 4360 | 131 | 10 | 4 | 1.671 |
| FOCAL ADHESION | 4510 | 197 | 11 | 3 | 1.436 |
| CELL ADHESION MOLECULES (CAMS) | 4514 | 149 | 4 | 3 | 1.428 |
| ENDOCYTOSIS | 4144 | 219 | 12 | 4 | 1.416 |
| REGULATION OF ACTIN CYTOSKELETON | 4810 | 215 | 11 | 4 | 1.379 |
| RENAL CELL CARCINOMA | 5211 | 71 | 7 | 2 | 1.133 |
| WNT SIGNALING PATHWAY | 4310 | 153 | 9 | 4 | 1.065 |
| VEGF SIGNALING PATHWAY | 4370 | 76 | 4 | 3 | 0.998 |
| ERBB SIGNALING PATHWAY | 4012 | 87 | 5 | 3 | 0.941 |
| TLR5-KO | |||||
| T CELL RECEPTOR SIGNALING PATHWAY | 4660 | 109 | 2 | 1 | 1.864 |
| AXON GUIDANCE | 4360 | 131 | 2 | 1 | 1.719 |
| CELL ADHESION MOLECULES (CAMS) | 4514 | 149 | 2 | 1 | 1.62 |
| FOCAL ADHESION | 4510 | 197 | 2 | 1 | 1.41 |
| REGULATION OF ACTIN CYTOSKELETON | 4810 | 215 | 2 | 1 | 1.346 |
| ENDOCYTOSIS | 4144 | 219 | 2 | 1 | 1.333 |
| ARGININE AND PROLINE METABOLISM | 330 | 53 | 1 | 1 | 1.087 |
| GLUTATHIONE METABOLISM | 480 | 54 | 1 | 1 | 1.079 |
| GLYCOLYSIS GLUCONEOGENESIS | 10 | 60 | 1 | 1 | 1.038 |
| RENAL CELL CARCINOMA | 5211 | 71 | 1 | 1 | 0.973 |
| TLR2-KO | |||||
| ARGININE AND PROLINE METABOLISM | 330 | 53 | 2 | 2 | 1.171 |
| GLUTATHIONE METABOLISM | 480 | 54 | 2 | 2 | 1.164 |
| T CELL RECEPTOR SIGNALING PATHWAY | 4660 | 109 | 8 | 4 | 1.106 |
| AXON GUIDANCE | 4360 | 131 | 9 | 4 | 1.098 |
| FOCAL ADHESION | 4510 | 197 | 13 | 3 | 1.049 |
| REGULATION OF ACTIN CYTOSKELETON | 4810 | 215 | 14 | 4 | 1.018 |
| ENDOCYTOSIS | 4144 | 219 | 11 | 4 | 0.975 |
| RENAL CELL CARCINOMA | 5211 | 71 | 8 | 3 | 0.888 |
| CELL ADHESION MOLECULES (CAMS) | 4514 | 149 | 7 | 4 | 0.875 |
| WNT SIGNALING PATHWAY | 4310 | 153 | 10 | 4 | 0.749 |
| TLR4-KO | |||||
| ADHERENS JUNCTION | 4520 | 74 | 12 | 4 | 2.242 |
| ARGININE AND PROLINE METABOLISM | 330 | 53 | 2 | 2 | 1.931 |
| GLUTATHIONE METABOLISM | 480 | 54 | 2 | 2 | 1.864 |
| PATHWAYS IN CANCER | 5200 | 323 | 21 | 4 | 1.808 |
| WNT SIGNALING PATHWAY | 4310 | 153 | 14 | 5 | 1.802 |
| AXON GUIDANCE | 4360 | 131 | 11 | 5 | 1.669 |
| REGULATION OF ACTIN CYTOSKELETON | 4810 | 215 | 15 | 5 | 1.504 |
| PROSTATE CANCER | 5215 | 89 | 10 | 3 | 1.363 |
| FOCAL ADHESION | 4510 | 197 | 12 | 4 | 1.265 |
| MAPK SIGNALING PATHWAY | 4010 | 271 | 16 | 5 | 1.22 |