Table 5.
Summary of findings—alternative hypoallergenic cultivars.
| Source | Number of Subjects | Food | Frequency of NO Symptoms to Highest Dose in FC N (%) | Symptom Severity in FC with Various Cultivars | Dose Eliciting Symptoms in FC with Various Cultivars |
|---|---|---|---|---|---|
| Asero et al. [27] | 7 | High allergenic Golden Delicious vs. low allergenic G-198/ Orim | GD: 0/7 (0.0) G-198/Orim: 0/7 (0.0) (p = NA) |
GD: median VAS score 2/10; range 2–8. G-198/Orim: median VAS score 4/10; range 2–8. 2/7 patients reported more severe OAS to GD than to G-198. 2/7 patients reported more severe symptoms to G-198 than to GD. 3/7 subjects reported identical severity of symptoms to both apple cultivars. |
NA, only 1 dose (15 g) |
| Bolhaar et al. [28] | 5 | High allergenic Golden Delicious vs. low allergenic Santana | No information | Mean VAS score after dose 1 (5 g): Santana < GD (p > 0.05); Mean VAS score after dose 2 (40 g): Santana < GD (p < 0.05); Mean VAS score after dose 3 (120 g): Santana < GD (p < 0.05) |
“The quantities needed to provoke a similar VAS score were on average 30 times higher for Santana than for GD apples (p < 0.001)” |
| Kootstra et al. [29] | 15 | High allergenic Golden Delicious vs. low allergenic Santana and Topaz | GD: 1/15 (6.7) Topaz: 1/15 (6.7) Santana: 8/15 (53.5) p (Santana vs. GD/Topaz) = 0.002 |
Maximum VAS score after dose 1 (20 g): Santana < GD (p = 0.017), Santana < Topaz (p = 0.004) |
No information |
| Vlieg-Boerstra et al. [30] | 33 | High allergenic Golden Delicious vs. Low-allergenic Elise, Santana and Pink Lady | 6–16%; no significant differences between GD, Elise, Santana and Pink Lady (p = NA). |
Cumulative VAS score after dose 1 (15 g): Elise < Santana (p = 0.02), Elise < PL (p = 0.04), Elise < GD (p < 0.001); Santana < GD (p = 0.05) |
No information |
GD = Golden Delicious; PL = Pink Lady; VAS = visual analogue score; NA = not available.