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. 2016 Aug 18;95(1):e10–e21. doi: 10.1111/aos.13227

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© 2016 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Acute ocular hypertension (AOH) causes the degeneration of RGC intraretinal axons. Retinal photomontages showing pNFH ⁺ intraretinal RGC axons in a control and an experimental retina. Below each photomontage is shown a magnification of the squared areas (A, B). In control retinas, pNFH expression is restricted to the middle and central retina while after AOH extends to the periphery. The abnormal pNFH expression in the AOH retinas depicts intensely stained RGCs (red arrows) as well as beaded axons (white arrows), showing the typical features of AOH‐induced retrograde axonal degeneration.