Aβ	amyloid-beta
AD	Alzheimer’s disease
Akt	protein kinase B
ALL	acute lymphocytic leukemia
APP	amyloid beta precursor protein
ATF6α	activating transcription factor 6 isoform α
ATM	ataxia-telangiectasia mutated
BBB	blood-brain barrier
Bcl-2	B-cell lymphoma 2
CDK	cyclin-dependent kinase
CDKI	cyclin-dependent kinase inhibitor protein
cGAS	cyclic GMP-AMP synthase
CIP/KIP	CDK interacting protein/kinase inhibitory protein
CML	chronic myelogenous leukemia
CNS	central nervous system
CSF	cerebrospinal fluid
DDR	DNA damage response
Ecrg4	esophageal cancer-related gene 4
EGF	epidermal growth factor
ER	endoplasmic reticulum
FGF-2	fibroblast growth factor 2
GLB1	galactosidase beta 1
HLA-DR	human leukocyte antigen-DR isotype
γH2AX	phosphorylated H2A histone family member X
IkB	inhibitor of kappa B
IL	Interleukin
MBP	myelin basic protein
MECP	methyl-CpG-binding protein
MMP	matrix metalloproteinase
MRI	magnetic resonance imaging
mTOR	mammalian target of rapamycin
MS	multiple sclerosis
NAWM	normal appearing white matter
NF-κB	nuclear factor kappa-light-chain-enhancer of activated B cells
NSCs	neural stem cells
OIS	oncogene-induced senescence
OPC	oligodendrocyte progenitor cell
PD	Parkinson’s disease
PS1	presenilin-1
p38MAPK	p38 mitogen-activated protein kinases
RB	Retinoblastoma
ROS	reactive oxygen species
RR-MS	relapsing-remitting multiple sclerosis
SA-β-Gal	senescence-associated β-galactosidase
SAHF	senescence-associated heterochromatin formation
SAMD	senescence-associated mitochondrial dysfunction
SASP	senescence-associated secretory phenotype
SIPS	stress-induced premature senescence
SIRT	Sirtuin
SP-MS	secondary progressive multiple sclerosis
SGZ	subgranular zone
STING	stimulator of IFN genes
SVZ	subventricular zone
S1P	sphingosine 1-phosphate receptor
TCDD	2,3,7,8-Tetrachlorodibenzo-p-Dioxin
Terc	human telomerase gene
TGF-β	transforming growth factor beta
TNF-α	tumour necrosis factor alpha
UPR	unfolded protein response
53BP1	p53-binding protein 1