Figure 4.

Effects of cisplatin, GRN A, and the combination of the two drugs on the expression of apoptotic related-proteins. (a) Western blot analysis. Cells were treated with cisplatin, GRN A, and the combination of the two drugs. The expression of some apoptotic genes, including BAX, Bcl-2, c-Myc, caspase-3, and phosphated-p53, were determined by western blot, as described in the materials and methods section. (b) Quantitative results of gene expression. (n ≥ 3, * p < 0.05, ** p < 0.01, *** p < 0.001).