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. 2018 Oct 10;19(10):3098. doi: 10.3390/ijms19103098

Figure 6.

Figure 6

TSPO ligand-induced ATP release. ATP release from human red blood cells was measured at 37 °C, 10% Hematocrit, as described in material and methods. Values are the ratio between extracellular ATP (ATPe) levels after and before the addition of TSPO ligands. Panel (A) shows the effect of 10 or 30 µM of PK 11195, Ro5-4864, NCS1016, and NCS1018. Panel (B) shows the effect of VDAC inhibitor Bcl-XLBH4 (10 µM), or Pannexin-1 inhibitors carbonexolone (CBX, 10 µM), or probenecid (PBC, 10 µM). Results are expressed as means ± SEM and considered different from basal (vehicle, unstimulated) values when * p < 0.05; ** p < 0.01 or from those incubated in the presence of Bcl-XLBH4 when # p < 0.05 and ## p < 0.01; N = 7.