Table 1.
Summary of the ATP binding site regions of GSK3β, CK1δ, DYRK1A, and CLK1. Five regions are found inside the ATP cavity and their respective residues are shown in a single letter code, as well as their sequence position that corresponds to each PDB file numbering.
| Glycine-Rich Region | Hydrophobic Pocket | Adenine Region | Sugar Pocket | Phosphate Binding Pocket | |
|---|---|---|---|---|---|
| GSK3β | GNGSFG 63-68 |
VAIK 82-85 |
LDYV 132-135 |
PQNLL 184-188 |
LKLCD 196-200 |
| CK1δ | GSGSFG 16-21 |
VAIK 35-38 |
MELL 82-85 |
PDNFL 131-135 |
VYIID 145-149 |
| DYRK1A | GKGSFG 166-171 |
VAIK 184-187 |
FEML 238-241 |
PENIL 290-294 |
IKIVD 303-307 |
| CLK1 | GEGAFG 168-173 |
VAVK 188-191 |
FELL 241-244 |
PENIL 291-295 |
IKVVD 312-325 |