Table 6.
Summary of absorption and distribution properties of the two best compounds 2a and 2e found on the four studied kinases. BBB: blood brain barrier, PPB: protein-protein binding, VDss: steady state volume of distribution, CNS: central nervous system.
| Absorption | Distribution | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Compound | Mol Weight | LogS | P-Glycoprotein | Caco-2 Permeability | Intestinal Absorption | LogP | BBB | PPB | VDss | CNS Permeability |
| Compound 2a | 351 | −6.1 | inactive | Moderate | 90.067 | 4.1 | 0.477 | High | 0.234 | −0.894 |
| Compound 2e | 290.1 | −5.7 | inactive | Moderate | 91.036 | 3.8 | 0.508 | High | 0.076 | −0.92 |