Table 7.

Summary of metabolism, excretion and toxicity properties of the two best compounds 2a and 2e found on the four studied kinases. CYP: cytochrome, OCT2: organic cation transporter 2, hERG: human ether-a-go-go gene, MRTD: maximum recommended tolerated dose.

	Metabolism	Excretion	Toxicity
Compound	CYP450	OCT2 Substrate	hERG	MRTD	AMES Toxicity	Hepatotoxicity
Compound 2a	Yes	No	<4.0	0.673	Yes	No
Compound 2e	Yes	No	<4.0	0.641	Yes	No