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The distribution of information gain, positive sample, and negative samples as a function of prediction score for (A) DisEMBL, (B) IUPred, (C) VSL2, and (D) ESpritz. The x-axis shows the prediction score, the y-axis on the left shows the values of information gain, and the y-axis on the right shows the fractions of positive samples and negative samples at different prediction scores, respectively.
