Table 3.

Comparison of prediction performance under five-fold cross-validation of eight predictors, as well as the new strategy trained for N-terminal, middle region, and C-terminal residues. The highest value in each of these measures is in bold and highlighted (red).

		DisEMBL	IUPred	VSL2	Espritz	PONDR-FIT	MFDp2	IUPred2	AUCpreD	This Work
N-ter	Sens	0.553 ± 0.009	0.541 ± 0.017	0.782 ± 0.011	0.582 ± 0.010	0.837 ± 0.004	0.782 ± 0.009	0.539 ± 0.015	0.748 ± 0.011	0.829 ± 0.023
	Spec	0.741 ± 0.016	0.841 ± 0.020	0.524 ± 0.024	0.789 ± 0.012	0.405 ± 0.020	0.582 ± 0.039	0.842 ± 0.020	0.590 ± 0.038	0.572 ± 0.049
	Acc	0.614 ± 0.003	0.639 ± 0.012	0.698 ± 0.005	0.650 ± 0.004	0.697 ± 0.006	0.718 ± 0.012	0.638 ± 0.014	0.697 ± 0.011	0.746 ± 0.014
	Acc-b	0.647 ± 0.004	0.691 ± 0.011	0.653 ± 0.010	0.686 ± 0.004	0.621 ± 0.011	0.682 ± 0.020	0.691 ± 0.014	0.669 ± 0.016	0.701 ± 0.020
	MCC	0.277 ± 0.009	0.364 ± 0.021	0.308 ± 0.019	0.349 ± 0.009	0.265 ± 0.024	0.361 ± 0.038	0.363 ± 0.027	0.330 ± 0.029	0.410 ± 0.035
	F1	0.660 ± 0.007	0.669 ± 0.015	0.778 ± 0.006	0.692 ± 0.008	0.789 ± 0.007	0.789 ± 0.007	0.668 ± 0.014	0.770 ± 0.010	0.815 ± 0.013
Middle	Sens	0.387 ± 0.009	0.682 ± 0.005	0.820 ± 0.004	0.481 ± 0.010	0.663 ± 0.004	0.777 ± 0.005	0.672 ± 0.005	0.539 ± 0.007	0.807 ± 0.013
	Spec	0.927 ± 0.001	0.877 ± 0.004	0.751 ± 0.004	0.948 ± 0.002	0.888 ± 0.004	0.875 ± 0.005	0.880 ± 0.004	0.927 ± 0.001	0.877 ± 0.006
	Acc	0.801 ± 0.004	0.831 ± 0.004	0.767 ± 0.003	0.839 ± 0.004	0.835 ± 0.004	0.852 ± 0.005	0.831 ± 0.004	0.836 ± 0.003	0.861 ± 0.004
	Acc-b	0.657 ± 0.005	0.780 ± 0.003	0.786 ± 0.003	0.715 ± 0.005	0.776 ± 0.003	0.826 ± 0.004	0.776 ± 0.003	0.732 ± 0.003	0.842 ± 0.005
	MCC	0.376 ± 0.009	0.544 ± 0.005	0.497 ± 0.006	0.506 ± 0.008	0.546 ± 0.006	0.616 ± 0.008	0.540 ± 0.007	0.510 ± 0.006	0.643 ± 0.008
	F1	0.477 ± 0.007	0.628 ± 0.003	0.622 ± 0.005	0.583 ± 0.008	0.653 ± 0.004	0.711 ± 0.004	0.650 ± 0.004	0.606 ± 0.005	0.731 ± 0.006
C-ter	Sens	0.584 ± 0.014	0.615 ± 0.017	0.847 ± 0.016	0.609 ± 0.019	0.828 ± 0.017	0.771 ± 0.016	0.598 ± 0.016	0.681 ± 0.013	0.790 ± 0.018
	Spec	0.787 ± 0.021	0.838 ± 0.023	0.586 ± 0.014	0.857 ± 0.015	0.615 ± 0.017	0.743 ± 0.015	0.845 ± 0.019	0.796 ± 0.019	0.769 ± 0.021
	Acc	0.686 ± 0.013	0.727 ± 0.005	0.715 ± 0.007	0.734 ± 0.009	0.720 ± 0.008	0.757 ± 0.007	0.723 ± 0.007	0.739 ± 0.009	0.780 ± 0.009
	Acc-b	0.685 ± 0.012	0.726 ± 0.006	0.716 ± 0.007	0.733 ± 0.007	0.721 ± 0.009	0.757 ± 0.007	0.722 ± 0.008	0.739 ± 0.008	0.780 ± 0.009
	MCC	0.379 ± 0.026	0.465 ± 0.014	0.448 ± 0.015	0.482 ± 0.015	0.453 ± 0.018	0.514 ± 0.014	0.459 ± 0.018	0.481 ± 0.018	0.560 ± 0.018
	F1	0.649 ± 0.012	0.691 ± 0.008	0.747 ± 0.008	0.694 ± 0.009	0.746 ± 0.008	0.759 ± 0.006	0.682 ± 0.012	0.722 ± 0.007	0.781 ± 0.006