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. 2018 Oct 10;10(10):1476. doi: 10.3390/nu10101476

Figure 5.

Figure 5

Effect of curcumin on SA β-gal activity and MCP-1 expression in mice. MF (standard feed), High-fat diet (HFD), 0.1% curcumin-mixed HFD (HFD + Cu), or 0.1% curcumin-mixed HFD plus SnMP (HFD + Cu + SnMP) was fed to mice for 72 weeks. (A) An increase in senescent cells in the thoracic aorta was analyzed by SA β-gal staining. (B) Expression of MCP-1 mRNA in the aorta was assessed by real-time RT-PCR. The expression level was standardized by GAPDH. (C) MCP-1 blood levels were measured by an MCP-1 ELISA kit. Data were presented in mean ± standard error for each group (n = 5). * P < 0.05 vs. y-CTL, † P < 0.05 vs. HFD, § P < 0.05 vs. HFD + Cu. SnMP, Stannous Mesoporphyrin; SA β-gal, senescence-associated β-galactosidase; y-CTL, 8 weeks old mice.